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Trans Fats may Increase Infertility Risk

NEW YORK - Women who desire to get pregnant may want to stay away from fast food french fries not just to stay away from putting on some extra pounds, a new study shows.

More trans fats a woman consumes, the more likely she is to be infertile, Dr. Jorge E. Chavarro of the Harvard School of Public Health in Boston and colleagues found.

Trans fats are found in fried foods, commercial baked goods, packaged snacks and other sources, and are known to raise the risk of heart disease and diabetes. "Even for someone who's not trying to get pregnant, it is a very good suggestion to stay away from them," Chavarro told Reuters Health.

Trans fats can interfere with the action of a cell receptor concerned in inflammation, insulin sensitivity and glucose metabolism, Chavarro and his team note in the American Journal of Clinical Nutrition. Drugs that trigger the receptor have been revealed to recover fertility in women with a condition known as polycystic ovary syndrome.

To examine how trans fat consumption may affect fertility, the researchers analyzed data from 18,555 healthy women participating in the Nurses' Health Study. All were married and trying to get pregnant between 1991 and 1999.

For each 2 percent boost in the amount of calories a woman got from trans fats as an alternative of carbohydrates, the researchers found, her risk of infertility increased by 73 percent. The risk rose by 79 percent for every 2 percent of energy in trans fats if they replaced omega-6 polyunsaturated fats. And for every 2 percent of calories derived from trans fats instead of monounsaturated fats, the risk of infertility more than doubled.

For a woman eating 1,800 calories a day, 2 percent of energy intake in trans fats equals 4 grams, Chavarro noted. "It's not very hard to get 4 grams of trans fatty acids every day," he said. "It's really a small quantity of trans fatty acids that we observe having a noteworthy effect on infertility."

The Food and Drug Administration now needs manufacturers to state on their label if a food has a half gram of trans fat per serving or more, Chavarro noted, but foods with less than a half gram are tolerable to claim that they have zero grams of trans fat. To cut trans fats out of the diet completely, he added, people should sstay away from all foods that list hydrogenated or partially hydrogenated oils in their ingredients.

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